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1.
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21 p, 2.7 MB |
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile
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De Luna, Luis Augusto Visani (Manchester Academic Health Science Centre) ;
Loret, Thomas (University of Manchester. Nanomedicine Lab) ;
Fordham, Alexander (University of Manchester. Nanomedicine Lab) ;
Arshad, Atta (University of Manchester. Nanomedicine Lab) ;
Drummond, Matthew (University of Manchester. National Graphene Institute) ;
Dodd, Abbie (University of Manchester. National Graphene Institute) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab)
A key aspect of any new material safety assessment is the evaluation of their in vivo genotoxicity. Graphene oxide (GO) has been studied for many promising applications, but there are remaining concerns about its safety profile, especially after inhalation. [...]
2022 -  10.1186/s12989-022-00502-w
Particle and fibre toxicology, Vol. 19 (September 2022) , art. 62
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2.
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19 p, 701.6 KB |
Engineering protein venoms as self-assembling CXCR4-targeted cytotoxic nanoparticles
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Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Protein venoms are effective cytotoxic molecules that when conveniently targeted to tumoral markers can be exploited as promising anticancer drugs. Here, it is explored whether the structurally unrelated melittin, gomesin, and CLIP71 could be functionally active when engineered, in form of GFP fusions, as self-assembling multimeric nanoparticles. [...]
2020 - 10.1002/ppsc.202000040
Particle & particle systems characterization, Vol. 37, Issue 6 (June 2020) , art. 2000040
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3.
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30 p, 1.5 MB |
Nanostructure empowers active tumor targeting in ligand-based molecular delivery
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López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sala, Rita (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Chardi, Alejandro (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez García, Laura 1992- (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Cell-selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor-mediated selective cell delivery. [...]
2019 - 10.1002/ppsc.201900304
Particle & particle systems characterization, Vol. 36, Issue 11 (November 2019) , art. 1900304
5 documents
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4.
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16 p, 2.3 MB |
Effects of differently shaped TiONPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier
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García-Rodríguez, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vila, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cortes Crignola, Constanza (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Background:The biological effects of nanoparticles depend on several characteristics such as size and shape that must be taken into account in any type of assessment. The increased use of titanium dioxide nanoparticles (TiO2NPs) for industrial applications, and specifically as a food additive, demands a deep assessment of their potential risk for humans, including their abilities to cross biological barriers. [...]
2018 - 10.1186/s12989-018-0269-x
Particle and fibre toxicology, Vol. 15 (August 2018) , art. 33
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5.
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6.
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12 p, 1.5 MB |
Altered characteristics of silica nanoparticles in bovine and human serum : The importance of nanomaterial characterization prior to its toxicological evaluation
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Izak-Nau, Emilia (University of Salzburg. Department of Molecular Biology) ;
Voetz, Matthias (Bayer Technology Services GmbH) ;
Eiden, Stefanie (Bayer Technology Services GmbH) ;
Duschl, Albert (University of Salzburg. Department of Molecular Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Background: Many toxicological studies on silica nanoparticles (NPs) have been reported, however, the literature often shows various conclusions concerning the same material. This is mainly due to a lack of sufficient NPs characterization as synthesized as well as in operando. [...]
2013 - 10.1186/1743-8977-10-56
Particle and fibre toxicology, Vol. 10 (November 2013) , art. 56
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7.
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15 p, 2.2 MB |
Shape matters : Effects of silver nanospheres and wires on human alveolar epithelial cells
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Stoehr, Linda C. (University of Salzburg. Department of Molecular Biology) ;
González, Edgar E. (Institut Català de Nanociència i Nanotecnologia) ;
Stampfl, Andreas (Helmholtz Centre Munich) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (University of Salzburg. Department of Molecular Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Oostingh, G. J. (University of Salzburg. Department of Molecular Biology)
Background: In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1. [...]
2011 - 10.1186/1743-8977-8-36
Particle and fibre toxicology, Vol. 8 (December 2011) , art. 36
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8.
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21 p, 792.0 KB |
Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects
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Oostingh, G. J. (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Italiani, Paola (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ;
Colognato, Renato (Italian Institute for Environmental Protection and Research) ;
Stritzinger, René (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Ponti, Jessica (Italian Institute for Environmental Protection and Research) ;
Pfaller, Tobias (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Kohl, Yvonne (Fraunhofer-Institut für Biomedizinische Technik) ;
Ooms, Daniëla (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ;
Favilli, Flavia (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ;
Leppens, Hilde (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ;
Lucchesi, Davide (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ;
Rossi, François (Italian Institute for Environmental Protection and Research) ;
Nelissen, Inge (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ;
Thielecke, Hagen (Fraunhofer-Institut für Biomedizinische Technik) ;
Puntes, Víctor (Institució Catalana de Recerca i Estudis Avançats) ;
Duschl, Albert (Universität Salzburg. Fachbereich Molekulare Biologie) ;
Boraschi, Diana (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche)
Background: With the increasing use of nanomaterials, the need for methods and assays to examine their immunosafety is becoming urgent, in particular for nanomaterials that are deliberately administered to human subjects (as in the case of nanomedicines). [...]
2011 - 10.1186/1743-8977-8-8
Particle and fibre toxicology, Vol. 8 (February 2011) , art. 8
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9.
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12 p, 1.1 MB |
Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions
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Stoehr, Linda C. (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ;
Endes, Carola (Universität Freiburg. BioNanomaterials, Adolphe Merkle Institute) ;
Radauer-Preiml, Isabella (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ;
Boyles, Matthew S. P. (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Balog, Sandor (Universität Freiburg. Soft Matter Scattering) ;
Pesch, Markus (Grimm Aerosol Technik GmbH & Co. KG, Ainring) ;
Petri-Fink, Alke (Universität Freiburg. BioNanomaterials, Adolphe Merkle Institute) ;
Rothen-Rutishauser, Barbara (Universität Freiburg. BioNanomaterials, Adolphe Merkle Institute) ;
Himly, Martin (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ;
Clift, Martin J. D. (Universität Freiburg. BioNanomaterials, Adolphe Merkle Institute) ;
Duschl, Albert (Paris-Lodron-Universität Salzburg. Department of Molecular Biology)
Stably transfected lung epithelial reporter cell lines pose an advantageous alternative to replace complex experimental techniques to monitor the pro-inflammatory response following nanoparticle (NP) exposure. [...]
2015 - 10.1186/s12989-015-0104-6
Particle and fibre toxicology, Vol. 12 (September 2015) , art. 29
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